Preheat oven to 425°F. Scrub the sweet potato clean under running water and pat dry.
Poke the sweet potato several times with a fork to allow steam to escape.
Rub the sweet potato with about 1 teaspoon olive oil and sprinkle with sea salt.
Place directly on the oven rack or on a baking sheet and roast 40–50 minutes, until fork-tender.
While it roasts, add cooked quinoa and chopped red onion to a mixing bowl.
Stir in minced spinach, crumbled feta, and minced garlic. Drizzle with lemon juice and 1/2 teaspoon olive oil; season with black pepper and toss to combine.
Remove the sweet potato from the oven and cool completely on a wire rack for at least 45 minutes.
Once cooled, cut the potato lengthwise without cutting through the bottom and gently open it.
Fluff the flesh slightly with a fork.
Pack the quinoa mixture into the sweet potato, pressing gently to fill.
Place the stuffed sweet potato in a glass meal prep container and seal with a lid.
Portion tzatziki into a small separate container.
Refrigerate immediately. Reheat potato in the microwave for about 90 seconds; add tzatziki cold after heating.